H2O2 stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4
نویسندگان
چکیده
Yujun Di, Emily J Holmes, Amna Butt, Keren Dawson, Aleksandr Mironov, Vassilios N Kotiadis, Campbell W Gourlay, Nic Jones* and Caroline RM Wilkinson* Cell Regulation Group, Paterson Institute for Cancer Research, University of Manchester, Manchester, UK, EM Core Facility, Faculty of Life Sciences, University of Manchester, Manchester, UK and Department of Biosciences, University of Kent, Canterbury Kent, UK
منابع مشابه
H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.
In fission yeast, the stress-activated MAP kinase, Sty1, is activated via phosphorylation upon exposure to stress and orchestrates an appropriate response. Its activity is attenuated by either serine/threonine PP2C or tyrosine phosphatases. Here, we found that the PP2C phosphatase, Ptc4, plays an important role in inactivating Sty1 specifically upon oxidative stress. Sty1 activity remains high ...
متن کاملDistinct regulatory proteins control the graded transcriptional response to increasing H2O2 levels in the fission yeast, S. pombe
The signaling pathways that sense adverse stimuli and communicate with the nucleus to initiate appropriate changes in gene expression are central to the cellular stress response. Here, we have characterized the role of the Sty1 (Spc1) stressactivated MAPK pathway, and the Pap1 and Atf1 transcription factors, in regulating the response to H2O2 in the fission yeast, Schizosaccharomyces pombe. We ...
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The mitogen-activated protein kinase (MAPK) Sty1 is essential for the regulation of transcriptional responses that promote cell survival in response to different types of environmental stimuli in Schizosaccharomyces pombe. In fission yeast, three distinct eukaryotic initiation factor 2alpha (eIF2alpha) kinases, two mammalian HRI-related protein kinases (Hri1 and Hri2) and the Gcn2 ortholog, reg...
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Spc1, an osmotic-stress-stimulated mitogen-activated protein kinase (MAPK) homolog in the fission yeast Schizosaccharomyces pombe, is required for the induction of mitosis and survival in high-osmolarity conditions. Spc1, also known as Sty1, is activated by Wis1 MAPK kinase and inhibited by Pyp1 tyrosine phosphatase. Spc1 is most closely related to Saccharomyces cerevisiae Hog1 and mammalian p3...
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